Efficacy of Vemurafenib in Hairy-Cell Leukemia
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چکیده
منابع مشابه
Hairy Cell Leukemia in a Young Male: An Unusual Presentation
Dear Editor-in-Chief A 28 yr male was presented in October 2015 at Medicine Outpatient Department, Safdarjung Hospital, New Delhi- India with generalized weakness, fever and cough for preceding 15 days. Clinicoradiologic examination revealed pallor, firm, non-tender splenomegaly measuring 13.7 cm and hepatomegaly (liver span - 16.9 cm). However, no lymphadenopathy was found.
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Hairy cell leukaemia variant is a very rare chronic lymphoproliferative disorder and is closely related to hairy cell leukemia. We hereby describe a case of hairy cell leukaemia variant for the first time in Saudi Arabia. An elderly Saudi man presented with pallor, massive splenomegaly, and moderate hepatomegaly. Hemoglobin was 7.7 g/dl, Platelets were 134 x109/l and white blood count was 140x1...
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In order to determine the nature of infectious complications in hairy-cell leukemia we studied 20 consecutive patients seen at UCLA and analyzed the available literature. The incidence of serious infection in our series was 40%, and pneumonia and septicemia due to Pseudomonas and E. coli organisms were the leading types of infections. Fungal infections with Cryptococci and Histoplasma organisms...
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AIRY CELL LEUKEMIA (HCL), or leukemic reticuH loendotheliosis, is a chronic lymphoproliferative disease that was first described as a distinct clinicopathologic entity by Bouroncle et a1 in 1958.' It is characterized by mononuclear cells of B-lymphocyte origin in the peripheral blood that have prominent cytoplasmic projections staining with tartrate-resistant acid phosphatase' and by its typica...
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Hairy cell leukemia (HCL) is a chronic mature B-cell neoplasm with unique clinicopathologic features and an initial exquisite sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly. The enigmatic pathogenesis of HCL was recently clarified by the discovery of its underlying genetic cause, the BRAF-V600E kinase-activating mutation, which is somatically an...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2014
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmc1310849